Plexium | A Comprehensive Drug Development Methodology
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. DRUGDEVELOPMENTREIMAGINED
A Comprehensive Drug Development Methodology

ABOUT US

Plexium is a technology-first drug development company. We develop ‘molecular glues’ that alter E3-ligase substrate recognition; inducing, inhibiting or modulating degradation of proteins for therapeutic benefit. Our deep engineering background allows us to screen for molecular-glue degraders in massively high throughput cell-based assays utilizing DNA-encoded libraries.

 

We also have the ability to capture transcriptional and proteomic responses of cells to very large chemical-libraries. This ability allows us to generate Perturbation | Response databases for hundreds of millions of compounds across various cell types. We intend to use the combination of phenotypic and target-specific screens to identify first-in-class therapeutics for challenging indications.

THERAPEUTIC FOCUS

We are interested in small-molecules that can be cures. As such, we are focused on immunomodulatory effects that can be gained from perturbing transcription factors and cytokine signalling pathways (via E3 ligase modulation). We are applying this approach to solid-tumors and neurodegenerative illnesses.

LEADERSHIP

teams_0004_Team1

Swamy Vijayan

CEO, Serial Entrepreneur

Ex. Illumina, Omniome

JohnBoylanPhD

John Boylan

Chief Scientific Officer

Ex. Celgene, Roche, Amgen

teams_0003_Team2

Neil Raheja

VP Chemistry

Ex. Celgene, Pfizer

Eben

Eben Massari

VP Screening and CNS

Ex. Dart, Kalpysys

yi

Yi Zhang

VP Engineering

Ex. Omniome, Celula

teams_0005_Team3

Mihai Azimiora

Director Chemistry

Ex. GNF, EJ Corey

Davorka

Davorka Messmer

Director Biology

Ex. Inception, UCSD

teams_0001_Team6

Pengyu Yang

Assays Cell Biology

Ex. CALIBR, Scripps

ADVISORS

teams_0000_Layer-1

Brian Paegel

Co-Founder, Advisor

Assoc. Professor TSRI

INVESTORS

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CONTACT US

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Address:

4202 Sorrento Valley Blvd, Suite A
San Diego, California 92121